High BMI in Early Pregnancy Causally Tied to Adverse Outcomes
By Lori Solomon HealthDay Reporter
WEDNESDAY, Feb. 7, 2024 -- There is a causal relationship between maternal pre-/early-pregnancy body mass index (BMI) and 14 of 20 adverse pregnancy and perinatal outcomes, according to a study published online Jan. 29 in BMC Medicine.
Maria Carolina Borges, Ph.D., from the University of Bristol in the United Kingdom, and colleagues explored the relation between maternal pre-/early-pregnancy BMI and 20 pregnancy and perinatal outcomes. The analysis included data from more than 400,000 women.
The researchers found that multivariable regression, Mendelian randomization, and paternal negative control analyses all supported associations of higher maternal BMI with lower odds of maternal anemia, delivering a small-for-gestational-age baby, and initiating breastfeeding. All three methods demonstrated higher odds of hypertensive disorders of pregnancy, gestational hypertension, preeclampsia, gestational diabetes, prelabor membrane rupture, induction of labor, caesarean section, large-for-gestational-age baby, high birthweight, low Apgar score at one minute, and neonatal intensive care unit admission. In a multivariable regression, higher maternal BMI was associated with a higher risk for gestational hypertension (odds ratio, 1.67), with similar results seen for Mendelian randomization (odds ratio, 1.59).
"Preconception interventions to support women maintaining a healthy BMI may reduce the burden of obstetric and neonatal complications," the authors write.
One author disclosed ties to the medical technology industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted February 2024
Read this next
Mortality in Rheumatic Heart Disease Is High
FRIDAY, June 7, 2024 -- Mortality related to rheumatic heart disease (RHD) is high and is correlated with the severity of valve disease, according to a study published online June...
Higher County-Level Prostate Cancer Screening Tied to Better Outcomes
FRIDAY, June 7, 2024 -- Higher county-level prevalence of prostate-specific antigen (PSA) screening is associated with lower odds of advanced disease, all-cause mortality, and...
Metabolic Impact on Offspring Similar for Frozen, Fresh Embryo Transfer
FRIDAY, June 7, 2024 -- For glucose and lipid profiles during early childhood, the impact of frozen embryo transfer (FET) is comparable to that of fresh embryo transfer, according...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.