Skip to main content

Digoxin Beneficial for Infants Palliated With Stage 1 Hybrid Procedure

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 4, 2024.

By Elana Gotkine HealthDay Reporter

THURSDAY, Jan. 4, 2024 -- For infants palliated with a stage 1 hybrid procedure, digoxin prescription at discharge is associated with a reduced risk for interstage death or transplant, according to a study recently published in the Journal of the American Heart Association.

Reshma K. Reddy, M.D., from the Shawn Jenkins Children's Hospital at the Medical University of South Carolina in Charleston, and colleagues conducted a retrospective multicenter cohort study using data from the National Pediatric Cardiology Quality Improvement Collaborative registry from 2008 to 2021 to examine whether digoxin prescription at discharge was associated with improved transplant-free interstage survival in infants following hybrid stage 1 palliation. A total of 259 infants were included from 45 sites; 61 percent had hypoplastic left heart syndrome.

Fifty percent of the infants were discharged on digoxin. The researchers found that 23 and 14 percent of patients in the no-digoxin and digoxin groups, respectively, had interstage death or transplant. Discharge digoxin prescription was associated with a reduced risk for interstage death or transplant in a multivariate analysis (adjusted odds ratio, 0.48).

"Based on these findings, it is reasonable to consider prescribing digoxin to infants who have undergone the stage 1 palliation hybrid procedure," the authors write.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2024 HealthDay. All rights reserved.

Posted January 2024

Read this next

Prevalence of Cardiovascular Risk Factors, Diseases Set to Increase

THURSDAY, June 6, 2024 -- The prevalence of cardiovascular risk factors and diseases will increase through 2050, and the associated economic burden is also projected to increase...

Adherence to Mediterranean Diet Linked to Lower Risk for Mortality

TUESDAY, June 4, 2024 -- Adherence to the Mediterranean diet is associated with a lower risk for all-cause mortality, which is partly explained by multiple cardiometabolic...

Gastrectomy for Gastric Cancer Tied to Lower Risk for Cardiovascular Events

TUESDAY, June 4, 2024 -- Patients with gastric cancer who undergo gastrectomy have a lower risk for cardiovascular events than the general population, according to a study...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.