Second-Line Switch to Dolutegravir Noninferior in HIV
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
FRIDAY, June 23, 2023 -- For patients with HIV without genotype information, a second-line switch to dolutegravir is noninferior to a regimen containing a ritonavir-boosted protease inhibitor (PI), according to a study published in the June 22 issue of the New England Journal of Medicine.
Loice A. Ombajo, M.B., Ch.B., from the University of Nairobi in Kenya, and colleagues conducted a prospective, open-label trial at four sites in Kenya involving patients without genotype information who had viral suppression while receiving treatment containing a ritonavir-boosted PI. Participants were randomly assigned to switch to dolutegravir or continue the current regimen (398 and 397, respectively). The primary end point was a plasma HIV type 1 RNA level of at least 50 copies/mL at week 48.
The researchers found that at week 48, 5.0 and 5.1 percent of patients in the dolutegravir and ritonavir-boosted PI groups, respectively, met the primary end point, a result that met the criterion for noninferiority. At the time of treatment failure, the investigators observed no mutations conferring resistance to dolutegravir or the ritonavir-boosted PI. A similar incidence of treatment-related grade 3 or 4 events was seen in the dolutegravir and ritonavir-boosted PI groups (5.7 and 6.9 percent, respectively).
"This trial provides information that can inform the current distribution of treatment regimens in Kenya and other similar settings, thus enabling consideration of a transition from ritonavir-boosted PI-based regimens to a dolutegravir-based regimen in almost 75 percent of patients currently receiving second-line therapy, which would provide advantages with regard to cost, risk of toxic effects, risk of drug-drug interactions, and pill burden," the authors write.
The study was funded by ViiV Healthcare, the manufacturer of dolutegravir.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted June 2023
Read this next
Voluntary Medical Male Circumcision May Reduce Risk for HIV Infection
TUESDAY, May 28, 2024 -- For men who have sex with men (MSM), voluntary medical male circumcision (VMMC) is associated with a reduced risk for HIV infection, according to a study...
Recommendations Developed for People With HIV Wanting to Breastfeed
MONDAY, May 20, 2024 -- In an American Academy of Pediatrics clinical report published online May 20 in Pediatrics, recommendations are presented for breastfeeding among people...
Cognitive Impairment Still Seen in Children, Teens With HIV
TUESDAY, April 30, 2024 -- Cognitive impairment persists in children and adolescents living with HIV even in the era of antiretroviral therapy (ART), according to research...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.