Soy, Enterolactone, Green Tea May Reduce Adverse Breast Cancer Outcomes
By Elana Gotkine HealthDay Reporter
TUESDAY, Jan. 23, 2024 -- Soy, enterolactone, and green tea are associated with reductions in adverse breast cancer outcomes, according to a systematic review and meta-analysis published in the February issue of JNCI Cancer Spectrum.
M. Diana van Die, Ph.D., from Western Sydney University in Penrith, Australia, and colleagues reviewed prospective and retrospective observational studies examining the impact of soybean, lignans, cruciferous vegetables, green tea, or their phytonutrients on breast cancer survival outcomes. Data were included from 32 studies.
The researchers found that the risk for recurrence was reduced in association with soy isoflavones (hazard ratio, 0.74), especially among postmenopausal and estrogen receptor-positive survivors (hazard ratios, 0.72 and 0.82, respectively), with the greatest reduction in risk seen at 60 mg/day. The reduction was mainly at 20 to 40 mg/day for mortality outcomes. An inverse association was seen for soy protein and soy products with cancer-specific mortality for estrogen receptor-positive disease (hazard ratio, 0.75). Serum or plasma enterolactone, measured prediagnosis and early postdiagnosis, was inversely associated with cancer-specific mortality and all-cause mortality (hazard ratios, 0.72 and 0.69, respectively). There were no effects observed for cruciferous vegetables. Prediagnostic green tea intake was associated with a reduced risk for recurrence for stage I and II breast cancer (hazard ratio, 0.56).
"To further inform clinical practice, evidence is required on the impact of dietary and supplemental intakes of phytonutrients introduced or substantially increased following diagnosis and treatment," the authors write.
Several authors disclosed ties to industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted January 2024
Read this next
Pandemic Had Temporary Negative Effect on Breast Cancer Screening
THURSDAY, May 30, 2024 -- The COVID-19 pandemic had a transient negative effect on breast cancer screening overall and a prolonged negative effect on follow-up screening...
Patient Characteristics Linked to Performance of AI Algorithm for DBT
THURSDAY, May 30, 2024 -- For analyzing negative screening digital breast tomosynthesis (DBT) examinations, patient characteristics influence the case and risk scores of an...
Chemo + Breast Cancer Combo Accelerates Functional Decline in Seniors
WEDNESDAY, May 29, 2024 -- The combination of breast cancer and chemotherapy contributes to accelerated functional decline in older women with early-stage breast cancer, according...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.