Uncontrolled Heart Risk Factors Common in Head, Neck Squamous Cell Cancer
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
THURSDAY, June 29, 2023 -- The burden of suboptimally controlled cardiovascular (CV) risk factors and incident risk of stroke and myocardial infarction (MI) are considerable in patients with head and neck squamous cell carcinoma (HNSCC), according to a study published online June 22 in JAMA Otolaryngology-Head & Neck Surgery.
Lova Sun, M.D., from the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, and colleagues defined CV risk profiles, incident stroke, MI, and mortality in patients with HNSCC in a retrospective, population-based cohort study including 35,857 U.S. veterans.
Most patients were taking risk-lowering medications, but 47 percent had one or more uncontrolled CV risk factor. The researchers found that Black race was associated with increased risk of having uncontrolled CV risk factors (relative risk, 1.06), and higher rates of prevalent and uncontrolled risk factors were seen for patients with larynx cancer versus other cancer subsites. The 10-year cumulative incidence of stroke and MI was 12.5 and 8.3 percent, respectively, considering death as a competing risk. Hypertension, diabetes, carotid artery stenosis, coronary artery disease, and presence of uncontrolled CV risk factor(s) were significantly associated with stroke and MI in cause-specific hazard models. Incident stroke and MI were associated with 47 and 71 percent increased risk of all-cause deaths, respectively, in extended Cox models.
"Owing to epidemiologic shifts and therapeutic advances, cancer prognosis for patients with HNSCC has improved during the past few decades," the authors write. "An improved understanding and focus on modifying CV risk is important in improving survivorship care and long-term outcomes for these patients."
Several authors disclosed ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted June 2023
Read this next
Delay in Hospital Arrival After Stroke Linked to Social Vulnerability
THURSDAY, May 30, 2024 -- Areas with a high incidence of delay in hospital arrival after ischemic stroke are characterized by increased social vulnerability, according to a study...
DNA Methylation-Based Epigenetic Age Mediates Link Between LE8 Score, CVD
WEDNESDAY, May 29, 2024 -- The associations between Life's Essential 8 (LE8) and cardiovascular health are mediated by DNA methylation-based epigenetic age, according to a study...
Infarct Size Does Not Affect Treatment Effect of Early Versus Late DOAC
TUESDAY, May 28, 2024 -- For individuals with minor, moderate, or major stroke, the treatment effect of early versus late direct oral anticoagulant (DOAC) initiation does not...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.